SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART
نویسندگان
چکیده
منابع مشابه
Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade
Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality worldwide, with myocardial infarction as the most common etiology. HF is characterized by β-adrenergic receptor (βAR) dysregulation that is primarily due to the upregulation of G protein-coupled receptor kinases that leads to overdesensitization of β1 and β2ARs, and this clinically manifests as a loss of i...
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Twenty-five years ago, it was known that heart failure was associated with an increase in sympathetic nervous activity, but the prevailing opinion was that this was a compensatory increase, in order to counteract depressed myocardial function, and that beta-blocker treatment might cause worsening heart failure. Consequently, beta-blockade was regarded as contraindicated in the treatment of pati...
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BACKGROUND Activation of the sympathetic nervous system has important prognostic implications in chronic heart failure. Nonselective versus selective beta-adrenergic receptor antagonists may have differential effects on norepinephrine release from nerve terminals mediated by prejunctional beta(2)-adrenergic receptors. METHODS AND RESULTS Thirty-six patients with chronic heart failure were ran...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1968
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1968.tb00444.x